ICSG2008 Presentation materials
>>Saturday, September 20th
>>Sunday, September 21st
>>Monday, September 22nd
>>Tuesday, September 23rd
>>Wednesday, September 24th
  Saturday, September 20th 
 3:00 – 5:00pm
Registration
 5:15 – 5:30pm
Introductory remarks
David Stuart, University of Oxford
Tom Terwilliger, Los Alamos National Laboratory
 5:30 – 6:30pm
Keynote Address :
Ian Wilson , The Scripps Research Institute:
Structural Genomics and The Expanding Protein Universe
 6:30 – 8:00pm
Welcome Drinks Reception
Poster session
Go to top

  Sunday, September 21st 
 9:00 – 10:30am
Session 1: Structural genomics, systems biology and complexes
Chairs: Anne-Claude Gavin and Rob Russell, EMBL Heidelberg
Andre Hoelz, Rockefeller University:
Building the nuclear pore complex piece by piece.
Achilleas Frangakis, EMBL-Heidelberg:
Towards identifying macromolecular complexes by cryo-electron tomography
Ben Luisi, University of Cambridge:
The multi-enzyme RNA degradosome and its connections to metabolism and gene expression
Sarah Teichmann, University of Cambridge :
Evolution and assembly of protein complexes
Discussion
 10:30 – 10:30am
Coffee break
 11:00 – 11:10am
Tools for Structural Genomics
Joe Ferrara, Rigaku
 11:10 – 1:00pm
Generating insight into protein function with structural genomics
Chair : Keith Wilson, University of York
Andrzej Joachimiak, Argonne National Laboratory :
Analyzing protein function with structural genomics
Gaetano Montelione, Rutgers University :
Structural Genomics Generates New Hypotheses for Biological Research
Anthony Kossiakoff, University of Chicago :
Harvesting the high-hanging fruit: crystallization chaperones
Cheryl Arrowsmith, SGC University of Toronto :
Functional information from structure and ligand binding
 1:00 – 2:00pm
Lunch
 2:00 – 3:30pm
Workshop - SG technologies: methodologies and dissemination (wet-lab)
Chair: Dino Moras, CERBM, Strasbourg
Frank H. Niesen , SGC Oxford and Toronto:
Differential Scanning Fluorimetry: Detection of ligands and conditions that promote protein stability and crystallization
D. Latek, Warsaw University:
CABS-NMR - a fast protein structure determination tool
 >>pdf (size: 2.0MB)
K. Clark, University of Rochester, NY :
Integral Membrane Protein Production from Yeast for the Center for High-Throughput Structural Biology
J.J. Liu,Scripps Research Institute: GPCR Structural Proteomics
A. May, Fluidigm, Berkeley:
Diffraction-Capable Microfluidic Crystallization Chips for Screening and Structure Determination
 3:30pm
free time
Go to top

  Monday, September 22nd 
 9:00 – 11:00am
Session 2: The impact of structural genomics on treating diseases
Chairs: Michael Sundström, University of Copenhagen and
Stephen Burley, Structural Genomix
Stephen Burley, Structural Genomix:
A structural genomics approach to human drug discovery targets : protein kinases, protein phosphatases, and nuclear hormone receptors
Stefan Knapp, SGC University of Oxford :
Regulation and selective inhibition of protein kinases
Christopher Austin, NIH Chemical Genomics Center:
The NIH Chemical Genomics Center Collaboration with the SGC to Develop Chemical Probes of Human Protein
 9:00 – 11:00am
Discussion
 11:00 – 11:30am
Coffee break
 11:30 – 12:30am
Keynote Address
Peter Donnelly, University of Oxford:
Genome-wide association studies and the genetics of common human diseases
 12:30 – 3:00am
Lunch and Poster Session
 3:00 – 4:30am
Structural determination, methods and computational tools
Chair: Gwyndaf Evans, Diamond Light Source Ltd
Zygmunt Derewenda, University of Virginia :
Improved crystallizability with surface mutations
 >>ppt.zip
(size: 10.8MB)
Anastassis Perrakis, Netherlands Cancer Institute :
ARP/WARP structure determination
 >>HTML
 >>pdf.zip
(size: 8.7MB)
 >>movie(iPod/iPhone)
mov.zip (size: 6.6MB)
Paul Adams, Lawrence Berkeley National Laboratory :
PHENIX -- automation of structure determination by x-ray crystallography
Wladek Minor,University of Virginia :
Protein Crystallography with Speed and Finesse, HKL-3000 Revisited
 4:30 – 5:00am
Coffee break
 5:00 – 6:00am
Keynote Address
Dino Moras,CERBM Strasbourg:
Structural characterization of some functional DNA-protein complexes
 6:30 – 9:00am
Drinks & canapé reception : Bodleian Library : Exhibition showcase of Dorothy Hodgkin memorabilia and items relating to Howard Florey's work on penicillin - £12 per head - tickets available from Registration desk - Saturday 20/Sunday 21 September
Go to top

  Tuesday, September 23rd 
 9:00 – 10:00am
International funding, co-operation and visions for the future
Chair: Tom Terwilliger, Los Alamos National Laboratory
Patrik Kolar, EC: EC perspective
John Norvell, NIGMS: US perspective
Yutaka Hishiyama,MEXT : Asia perspective
Visions for the future:
Shigeyuki Yokoyama, RIKEN Genomic Sciences Center
Ian Wilson, The Scripps Research Institute
David Stuart, University of Oxford
Ted Baker,The University of Auckland
Roundtable discussion
 10:00 – 11:00am
Session 3: Maximising impact on and integration with biology
Chairs: Ian Wilson, The Scripps Research Institute and
Zihe Rao,Tsinghua University
Zihe Rao, Tsinghua University:
Structural Genomics in China
Bruno Canard, AFMB Marseille:
The VIZIER project: from viral genomics to structure-based drug design against RNA virus replication enzymes
Rui-Ming Xu, Cold Spring Harbor Laboratory:
Structural Studies of Epigenetic control of Gene Expression
Helen Berman, Rutgers University:
PSI Structural Genomics Knowledgebase: Integrated access to PSI products for all of biology
 >>ppt.zip
(size: 6.3MB)
 11:00 – 11:30am
Coffee break
 11:00 – 1:00pm
Session 4: HTP methods for membrane proteins
Chairs: Robert Stroud, UCSF and
Neil Isaacs, University of Glasgow
Gebhard Schertler, LMB, Cambridge:
Structure of adrenergic receptors: progress in obtaining recombinant GPCR structures
Peter Henderson, University of Leeds:
Structural genomics approaches to bacterial membrane transport and receptor proteins
Eva Pebay-Peyroula, IBS Grenoble:
Structural studies of mitochondrial carriers
Robert Stroud, UCSF :
Discovery-Oriented Eukaryotic Integral Membrane Protein Over-expression and Purification
 11:00 – 1:00pm
Discussion
 1:00 – 2:00pm
Lunch
 2:00 – 3:30pm
Workshop - Focused activity
Chair: David Stuart, University of Oxford
James Naismith, University of St. Andrews:
Highlights from the SSPF
M. Wilmanns, EMBL-Hamburg:
The proteome of Mycobacterium tuberculosis in 3D: towards structure-based Drug discovery
Bridget Mabbutt, Macquarie University:
Structural genomics of the bacterial mobile metagenome: proteins pooled within integron/cassette arrays
Fuyuhiko Inagaki, Hokkaido University:
Structural Biology of Autophagy
Scott Lesley, GNF San Diego:
The Structure of a Two component, pseudo-tetrameric, potassium uptake complex, TrkA, from Thermotoga maritime.
Darren Hart,EMBL-Grenoble:
Library-based construct screening for difficult to express proteins using Influenza polymerase as a test case.
Stephen Graham, University of Oxford:
Structural insights into the evolution of poxvirus immune modulation
 3:30 – 4:00pm
Coffee Break
 4:00 – 5:30pm
Session 5: Hybrid/multidisciplinary approaches
Chairs: Carol Robinson, University of Cambridge and Michael Rossmann, Purdue University
Michael Rossmann, Purdue University:
Virus Maturation
 >>ppt.zip
(size: 34MB)
Carol Robinson, University of Cambridge:
From Nanodroplets to Protein Networks
Paul Freemont,Imperial College London:
A hybrid structural biology approach aimed at understanding the mechanism and function of the AAA ATPase p97/VCP
Sarah Butcher, University of Helsinki:
TBA
Discussion
Go to top

  Wednesday, September 24th 
 9:00 – 10:30am
Session 6: Strategies for intrinsically unfolded proteins
Chairs: Petér Tompa, Institute of Enzymology, Budapest and Joel Sussman, Weizmann Institute
Yosef Shaul, Weizmann Institute:
IUPs : strategies of degradation and regulation
Lucia Banci, CIRMMP,
Florence: An NMR contribution to the study of unfolded protein states
Dmitri Svergun,EMBL-Hamburg:
Structural analysis of intrinsically unfolded proteins by small-angle X-ray scattering
Colin Kleanthous, University of York:
Role of Intrinsic Disorder in Membrane Translocation
Discussion
 10:30 – 10:35am
Presentation of Best Poster Prize: Tom Terwilliger
 10:35 – 11:00am
Coffee break
 11:00 – 12:30am
Session 7: Should we expand the protein universe or concentrate on biology?
Chairs: Andrzej Joachimiak, Argonne National Laboratory and
Ted Baker, University of Auckland
Adam Godzik, Burnham Institute for Medical Research :
What the structure of the protein universe tells us about the evolution of life
John Moult, University of Maryland:
Breadth versus focus in Structural Genomics
Discussion
 12:30 – 1:15pm
Keynote Address
Neil Isaacs, University of Glasgow:
High throughput and membrane proteins - the MPSI experience
 1:15 – 1:30pm
Joel Sussman, Weizmann Institute of Science :
Proteopedia - a scientific 'wiki' bridging the rift between 3D structure and function of biomacromolecules
>>flv.zip
(size: 98.5MB)
 1:30 – 2:30pm
Lunch
 2:30 – 3:30pm
Workshop - Large Scale Activities
Chair: Gaetano Montelione :Rutgers University
John Markley, University of Wisconsin and
Center for Eukaryotic Structural Genomics (CESG):

Platform for Eukaryotic Structural Genomics
 >>ppt.zip
(size: 7.6MB)
 >>vcf.zip
(size: 500B)
James Love, New York Structural Biology Centre and New York Consortium for Membrane Protein Structure (NYCOMPS):
High Throughput Membrane Protein Production at NYCOMPS
Janet Huang, Rutgers University and Northeast Structural Genomics Consortium (NESG):
Structural Genomics of Protein-Interaction Pathways Associated with Human Cancer Biology
Marek Grabowski, University of Virginia Midwest Centre for Structural Genomics (MCSG):
Keeping Up with the Expanding Knowledge of the Protein Universe: The Impact of Structural Genomics
 3:30 – 4:30pm
Keynote Address
Chas Bountra, SGC Oxford:
Structure to Probe to Medicine
 4:30 – 5:00pm
Coffee break
 5:00 – 6:30pm
Session 8: New Technologies
Chairs: Lance Stewart, Decode Bio-structures and Soichi Wakatsuki, Photon Factory, Japan
Oliver Lange, University of Washington:
Towards high resolution structure determination with incomplete NMR or X-ray data
Shigeyuki Yokoyama, Riken:
Cell-free and cell-based production of human protein complexes and membrane proteins
Jochen Müller-Dieckmann, EMBL-Hamburg:
Crystal growth and in situ analysis with a micro-fluidic chip
Robert Fischetti, Argonne National Laboratory:
Reduce Radiation Damage with a One Micron Beam
 6:30pm
Meeting Closed
 7:30pm
Coach pickup: Dinner at Blenheim Palace Orangerie After dinner speaker: Professor Guy Dodson: "Dorothy Hodgkin - discoveries in chemistry and biology through crystallography"
Go to top
last update : Nov 25, 2008


Copyright (c) ISGO Executive Committee. All rights reserved.