9:00 – 10:00am
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International funding, co-operation and visions for the future
Chair: Tom Terwilliger, Los Alamos National Laboratory
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Patrik Kolar, EC: EC perspective
John Norvell, NIGMS: US perspective
Yutaka Hishiyama,MEXT : Asia perspective
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Visions for the future:
Shigeyuki Yokoyama, RIKEN Genomic Sciences Center
Ian Wilson, The Scripps Research Institute
David Stuart, University of Oxford
Ted Baker,The University of Auckland
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Roundtable discussion
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10:00 – 11:00am
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Session 3: Maximising impact on and integration with biology
Chairs: Ian Wilson, The Scripps Research Institute and Zihe Rao,Tsinghua University
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Zihe Rao, Tsinghua University: Structural Genomics in China
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Bruno Canard, AFMB Marseille: The VIZIER project: from viral genomics to structure-based drug design against RNA virus replication enzymes
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Rui-Ming Xu, Cold Spring Harbor Laboratory: Structural Studies of Epigenetic control of Gene Expression
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Helen Berman, Rutgers University: PSI Structural Genomics Knowledgebase: Integrated access to PSI products for all of biology
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11:00 – 11:30am
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Coffee break
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11:00 – 1:00pm
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Session 4: HTP methods for membrane proteins
Chairs: Robert Stroud, UCSF and Neil Isaacs, University of Glasgow
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Gebhard Schertler, LMB, Cambridge: Structure of adrenergic receptors: progress in obtaining recombinant GPCR structures
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Peter Henderson, University of Leeds: Structural genomics approaches to bacterial membrane transport and receptor proteins
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Eva Pebay-Peyroula, IBS Grenoble: Structural studies of mitochondrial carriers
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Robert Stroud, UCSF : Discovery-Oriented Eukaryotic Integral Membrane Protein Over-expression and Purification
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11:00 – 1:00pm
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Discussion
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1:00 – 2:00pm
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Lunch
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2:00 – 3:30pm
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Workshop - Focused activity
Chair: David Stuart, University of Oxford
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James Naismith, University of St. Andrews: Highlights from the SSPF
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M. Wilmanns, EMBL-Hamburg: The proteome of Mycobacterium tuberculosis in 3D: towards structure-based
Drug discovery
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Bridget Mabbutt, Macquarie University: Structural genomics of the bacterial mobile metagenome: proteins pooled within integron/cassette arrays
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Fuyuhiko Inagaki, Hokkaido University: Structural Biology of Autophagy
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Scott Lesley, GNF San Diego: The Structure of a Two component, pseudo-tetrameric, potassium uptake complex, TrkA, from Thermotoga maritime.
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Darren Hart,EMBL-Grenoble: Library-based construct screening for difficult to express proteins using Influenza polymerase as a test case.
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Stephen Graham, University of Oxford: Structural insights into the evolution of poxvirus immune modulation
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3:30 – 4:00pm
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Coffee Break
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4:00 – 5:30pm
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Session 5: Hybrid/multidisciplinary approaches
Chairs: Carol Robinson, University of Cambridge and Michael Rossmann, Purdue University
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Michael Rossmann, Purdue University: Virus Maturation
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Carol Robinson, University of Cambridge: From Nanodroplets to Protein Networks
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Paul Freemont,Imperial College London: A hybrid structural biology approach aimed at understanding the mechanism and function of the AAA ATPase p97/VCP
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Sarah Butcher, University of Helsinki: TBA
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Discussion
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